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Environmental Health and Toxicology 2019;e2019004. doi: https://doi.org/10.5620/eht.e2019004    [Accepted]
Toxicity of Four Parabens and Their Mixture Effects Using Daphnia magna and Vibrio fischeri
Jaewoong Lee1, Seung Hyuck Bang1, Yang-Hoon Kim2, Jiho Min1
1Chonbuk National University, Jeonju, Korea
2Chungbuk National Univeristy, Cheongju, Korea
Corresponding Author: Jiho Min ,Tel: 82-63-270-2436, Fax: 82-63-270-2306, Email: jihomin@jbnu.ac.kr
Received: April 18, 2018;  Accepted: August 21, 2018.
ABSTRACT
In this study, we investigated the risk of toxicity by treating two or more parabens in aquatic microorganisms differentially. First, each paraben was treated to Daphnia magna (D. magna) to measure the toxicity levels as LC20 (lethal concentration 20%) LC50 (lethal concentration 50%). The results showed their value of methyl paraben(MP) (25.2mg/l, 73.4mg/l), ethyl paraben(EP) (18.4mg/L, 43.7mg/L), n-propyl paraben(PP) (10.4mg/L, 21.1mg/L) and n-butyl paraben(BP)(3.3mg/l, 11.2mg/l). Then, each of the parabens was treated to Vibrio fischeri (V. fischeri) and calculated their EC20(effective concentration 20%) and EC50(effective concentration 50%) by bioluminescence inhibition test. The results showed the values of MP(2.93mg/l, 16.8mg/l), EP(1.18mg/l, 6.74mg/l), PP(0.51mg/l, 5.85mg/l)and BP(0.21mg/l, 2.34mg/l). These four parabens belong to the group classified as being ?쁥armful to aquatic organisms??(above 10 mg/L, below 100mg/L). After measuring the toxicity, EC20 values of two or more parabens were tested in order to investigate their toxicity. Thus, ten samples were measured (M + E, M + P, M + B ... E + P + B). As a result, the bioluminescence inhibition of V. fischeri presented that the toxicity of the mixture parabens was stronger than that of the single compound and measured the highest bioluminescence inhibition in the three paraben mixtures. The results show that independent toxicity of paraben was maintained, moreover the mixture toxicity of the paraben is predictable by substrate addition.
Keywords: Paraben; Daphnia magna; Vibrio fisheri
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Toxicities of Four Parabens and Their Mixtures to Daphnia magna and Aliivibrio fischeri  2018 December;33(4)
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