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Journal of Environmental Toxicology 2008;23(4):285-290.
티타늄 금속나노입자의 혈액응고작용 검색
박광식
Screening Test of Titanium Dioxide Nanoparticles on Blood Coagulation and Platelet Aggregation
Kwangsik Park
ABSTRACT
  Effects of titanium dioxide nanoparticles on blood coagulation and platelet aggregation were investigated using diluted whole blood and platelet rich plasma (PRP) solution prepared from human and rat blood, respectively. Blood coagulation was monitored by using a whole blood impedance aggregometer and titanium dioxide nanoparticle (10, 20, and 40 ppm) did not show any effect on the coagulation both in human and in rat blood. When platelet aggregation was measured by turbidometric method after addition of titanium dioxide nanoparticles to PRP solution with final concentrations of 1, 5 and 10 ppm. no aggregation was observed.
Keywords: titanium dioxide nanoparticles; blood coagulation; platelet aggregation
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