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Korean Journal of Environmental Toxicology 2017;0:e2017017. doi: https://doi.org/10.5620/eht.e2017017    [Accepted]
From specific Humidifier disinfectants disease to Humidifier disinfectants syndrome
Jong-Han Leem1 , Jong-Hyeon Lee2
1Departement of Occupational and Environmental Medicine Inha University College of Medicine, Incheon, Korea
2EH Research & Consulting, Seoul, Korea
Corresponding Author: Jong-Han Leem ,Tel: 032-890-3539, Fax: 032-890-2859, Email: ekeeper21@naver.com
Received: July 6, 2017;  Accepted: October 7, 2017.
ABSTRACT
Humidifier disinfectant damage was terrible chemical damage caused by household goods that happened in only South Korea, but it is still very little known in humidifier disinfectant damage. Up to now, previous research tried to focus on interstitial fibrosis on terminal bronchiole and alveoli because it is specific finding, compared with other diseases. To figure out overall effects from HDs, many epidemiologic and toxicologic research is underway. Humidifier disinfectants showed to give rise to typical toxicologic effects on various target organs, such as skin, conjunctiva, naval mucosa, bronchial mucosa, alveoli and so on, which were sharing common toxicological responses. On specific target, specific toxicologic effects existed. Diverse diseases along exposure pathways can occur at the same time with common toxicologic mechanism and cause of humidifier disinfectants, which can be called as humidifier disinfectants syndrome. To gain more strong scientific evidence about it, further epidemiological and toxicological studies should be applied.
Keywords: Humidifier disinfectants syndrome; Humidifier disinfectants lung injury; Asthma; ROS; Common toxicologic mechanism
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